Adipic Acid → HCID 70523839, compound

HRID 1758200Notes

Reaction equation

HRID 1758200 reaction equation
[O:1]1[CH2:18][CH:2]1[CH2:3][N:4]1[C:13]([CH3:15])([CH3:14])[CH2:12][C:7]2([O:11][CH2:10][CH2:9][O:8]2)[CH2:6][C:5]1([CH3:17])[CH3:16].[C:19]([OH:28])(=[O:27])[CH2:20][CH2:21][CH2:22][CH2:23][C:24]([OH:26])=[O:25].[C:29]([O:32][CH2:33][CH3:34])(=[O:31])[CH3:30]>C1(C)C(C)=CC=CC=1>[OH:1][CH:2]([CH2:3][N:4]1[C:5]([CH3:16])([CH3:17])[CH2:6][C:7]2([O:8][CH2:9][CH2:10][O:11]2)[CH2:12][C:13]1([CH3:14])[CH3:15])[CH2:18][O:25][C:24](=[O:26])[CH2:23][CH2:22][CH2:21][CH2:20][C:19]([O:28][CH2:18][CH:2]([OH:1])[CH2:3][N:4]1[C:5]([CH3:17])([CH3:16])[CH2:6][C:29]2([O:31][CH2:34][CH2:33][O:32]2)[CH2:30][C:13]1([CH3:14])[CH3:12])=[O:27]

Participants

5

Reactant 3

HCID 196Adipic AcidHCID 8857Ethyl AcetateHCID 20481857HCID 20481857, compound

Product 1

HCID 70523839HCID 70523839, compound

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

A mixture of 10 g of 8-(2,3-epoxypropyl)-7,7,9,9-tetramethyl-1,4-dioxa-8-azaspiro[4.5]decane and 2.4 g of adipic acid in 60 ml of xylene was refluxed for 16 hours. After completion of the reaction, the residue obtained by evaporating the solvent under reduced pressure from the reaction mixture was purified by column chromatography through silica gel eluted with a 1:1 by volume mixture of ethyl acetate and benzene. The desired Compound No. 208 was obtained in the form of a pale yellow, viscous product. The compound had an Rf value of 0.53 on thin-layer chromatography on silica gel developed with ethyl acetate.

Workup

  1. temperaturewas refluxed for 16 hours
  2. customAfter completion of the reaction
  3. customthe residue obtained
  4. customby evaporating the solvent under reduced pressure from the reaction mixture
  5. customwas purified by column chromatography through silica gel
  6. washeluted with a 1:1 by volume mixture of ethyl acetate and benzene
  7. custom208 was obtained in the form of a pale yellow, viscous product

Sources & evidence

ORD record
ord-f13778286cfb409b8d4d11b467e9ece4
Source dataset
uspto-grants-1983_02
Patent number
US04371644

Reaction notes

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