Dimethylformamide → HCID 54496467, compound

HRID 1758405Notes

Reaction equation

HRID 1758405 reaction equation
O[CH:2]([C:8](=[O:10])[CH3:9])[C:3]([O:5][CH2:6][CH3:7])=[O:4].[Cl:11][C:12]1[CH:19]=[CH:18][C:15](CCl)=[CH:14][CH:13]=1.[C:20](=[O:23])([O-])[O-].[K+].[K+].C[N:27](C)C=O>C(OCC)(=O)C>[Cl:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:20][O:23][N:27]=[C:2]([C:8](=[O:10])[CH3:9])[C:3]([O:5][CH2:6][CH3:7])=[O:4])=[CH:14][CH:13]=1

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 77231-Chloro-4-(chloromethyl)benzeneHCID 11430Potassium CarbonateHCID 13659528HCID 13659528, compound

Product 1

HCID 54496467HCID 54496467, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Ethyl 2-hydroxy-3-oxobutyrate (syn isomer, 74.12 g.), 4-chlorobenzyl chloride (50.0 g.), potassium carbonate (64.4 g.), N,N-dimethylformamide (50 ml.), and ethyl acetate (50 ml.) were treated in a similar manner to that of Example A-(1) to give ethyl 2-(4-chlorobenzyloxyimino)-3-oxobutyrate (syn isomer, 75.93 g.).

Sources & evidence

ORD record
ord-a075fb563f524e7695db5f178229f96a
Source dataset
uspto-grants-1983_02
Patent number
US04372952

Reaction notes

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