2-Amino-5-(trifluoromethyl)pyridine → HCID 13023075, compound

HRID 1758927Notes

Reaction equation

HRID 1758927 reaction equation
[Cl:1][C:2]1[CH:12]=[CH:11][CH:10]=[C:9]([Cl:13])[C:3]=1[C:4]([N:6]=[C:7]=[O:8])=[O:5].[F:14][C:15]([F:24])([F:23])[C:16]1[CH:17]=[CH:18][C:19]([NH2:22])=[N:20][CH:21]=1>C(OCC)(=O)C>[Cl:1][C:2]1[CH:12]=[CH:11][CH:10]=[C:9]([Cl:13])[C:3]=1[C:4]([NH:6][C:7]([NH:22][C:19]1[CH:18]=[CH:17][C:16]([C:15]([F:23])([F:14])[F:24])=[CH:21][N:20]=1)=[O:8])=[O:5]

Participants

4

Reactant 2

HCID 7358622-Amino-5-(trifluoromethyl)pyridineHCID 129127392,6-Dichlorobenzoyl isocyanate

Product 1

HCID 13023075HCID 13023075, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A 1.1 g. portion of 2,6-dichlorobenzoyl isocyanate and 0.8 g. of 5-trifluoromethyl-2-aminopyridine were mixed in 50 ml. of ethyl acetate at ambient temperature and stirred for 18 hours. The solvent was then evaporated and the product was recrystallized from ethanol to obtain 0.2 g. of the product named above, m.p. 228°-230° C. Elemental analysis showed:

Workup

  1. customThe solvent was then evaporated
  2. customthe product was recrystallized from ethanol
  3. customto obtain 0.2 g

Sources & evidence

ORD record
ord-6658c6aa6d134f4f860d92b46877d65d
Source dataset
uspto-grants-1982_07
Patent number
US04338321

Reaction notes

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