Benzyl Bromide → HCID 13117017, compound

HRID 1759258Notes

Reaction equation

HRID 1759258 reaction equation
[OH:1][C:2]1[CH:3]=[N:4][O:5][CH:6]=1.[CH2:7](Br)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:7]([O:1][C:2]1[CH:3]=[N:4][O:5][CH:6]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

5

Reactant 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 131170124-hydroxyisoxazole

Product 1

HCID 13117017HCID 13117017, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
25 °C

Procedure

A mixture containing 200 mg of 4-hydroxyisoxazole in 10 ml of acetone together with 1.5 equivalents of benzyl bromide and 1.5 equivalents of potassium carbonate is stirred at about 25° C. for five hours. The solid is filtered and the filtrate concentrated to an oil. The crude material is purified by chromatography on silica gel.

Workup

  1. filtrationThe solid is filtered
  2. concentrationthe filtrate concentrated to an oil
  3. customThe crude material is purified by chromatography on silica gel

Sources & evidence

ORD record
ord-8b06d7e984b2497ea462637c04ad794f
Source dataset
uspto-grants-1982_07
Patent number
US04339588

Reaction notes

Loading…