Pyrrolidine → HCID 12152140, compound

HRID 1759667Notes

Reaction equation

HRID 1759667 reaction equation
[NH2:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4](Cl)[N:3]=1.O1CCOCC1.[NH:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1>O>[NH2:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([N:18]2[CH2:22][CH2:21][CH2:20][CH2:19]2)[N:3]=1

Participants

5

Reactant 3

HCID 31268PyrrolidineHCID 312751,4-DioxaneHCID 27240356-Chloro-3-nitropyridin-2-ylamine

Product 1

HCID 12152140HCID 12152140, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2 g (0.012 mol) of 2-amino-6-chloro-3-nitropyridine, 30 ml of dioxane and 20 ml of water, and 1.8 g of pyrrolidine are charged to a fully equipped round-bottomed flask. The mixture is brought to 70° C. for one hour with stirring and then the mixture is poured onto an ice/water mixture with stirring. The precipitate formed is filtered off and dried. 2.2 g of yellow powder are obtained, Yd=88%.

Workup

  1. stirringwith stirring
  2. customThe precipitate formed
  3. filtrationis filtered off
  4. customdried

Sources & evidence

ORD record
ord-17aeeb893b0d457bb1e5746ba3ae935e
Source dataset
uspto-grants-2005_01
Patent number
US06837908B2

Reaction notes

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