Triethylsilane → HCID 22595762, compound

HRID 1760532Notes

Reaction equation

HRID 1760532 reaction equation
[CH2:1]([N:4]1[C:9]2[CH:10]=[CH:11][C:12]([S:14][CH3:15])=[CH:13][C:8]=2[CH:7](O)[C:6]([CH3:18])([CH3:17])[S:5]1(=[O:20])=[O:19])[CH:2]=[CH2:3].C([SiH](CC)CC)C.C(=O)(O)[O-].[Na+]>FC(F)(F)C(O)=O>[CH3:17][C:6]1([CH3:18])[CH2:7][C:8]2[CH:13]=[C:12]([S:14][CH3:15])[CH:11]=[CH:10][C:9]=2[N:4]([CH2:1][CH:2]=[CH2:3])[S:5]1(=[O:20])=[O:19]

Participants

5

Reactant 3

HCID 12052TriethylsilaneHCID 516892Sodium BicarbonateHCID 22595726HCID 22595726, compound

Product 1

HCID 22595762HCID 22595762, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

3,4-Dihydro-1-(prop-2-en-1-yl)-3,3-dimethyl-6-methylthio-1H-2,1-benzothiazin-4-ol 2,2-dioxide (1.8 g; 0.0053 m) was dissolved in trifluoroacetic acid (30 mL) and triethylsilane (15 mL) was added in one portion. After stirring for 4 hrs, the reaction was reduced to an oil under vaccuo and after the addition of saturated sodium bicarbonate, the product extracted with dichloromethane, dried, filtered and isolated as a colourless solid.(1.6 g; 93%)

Workup

  1. extractionthe product extracted with dichloromethane
  2. customdried
  3. filtrationfiltered
  4. customisolated as a colourless solid

Sources & evidence

ORD record
ord-40a90e181c1c46e89c73f9fbf0912a59
Source dataset
uspto-grants-2005_01
Patent number
US06844338B2

Reaction notes

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