Hydrochloric Acid → HCID 68890109, compound

HRID 1760593Notes

Reaction equation

HRID 1760593 reaction equation
C(OC)(C)(C)C.[F:7][C:8]1[CH:16]=[C:15]([CH3:17])[C:14]2[N:13]3[C@H:18]([CH3:23])[CH2:19][NH:20][C:21](=O)[C:12]3=[CH:11][C:10]=2[CH:9]=1.[ClH:24]>ClCCl.C(OCC)C>[ClH:24].[F:7][C:8]1[CH:16]=[C:15]([CH3:17])[C:14]2[N:13]3[C@H:18]([CH3:23])[CH2:19][NH:20][CH2:21][C:12]3=[CH:11][C:10]=2[CH:9]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 15413tert-Butyl methyl etherHCID 20824954HCID 20824954, compound

Product 1

HCID 68890109HCID 68890109, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

The tide compound (ISP-MS: m/e 219.3 ([M+H]+)) was produced in accordance with the general method of example 1a), using tert-butyl-methyl ether instead of tetrahydrofuran as solvent, from (R)-8-fluoro-4,6-dimethyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one. The product (20 mg) was dissolved in dichloromethane and treated with a solution of HCl in diethyl ether to precipitate the hydrochloride salt Yield: 18 mg.

Workup

  1. customThe tide compound (ISP-MS: m/e 219.3 ([M+H]+)) was produced in accordance with the general method of example 1a),
  2. customto precipitate the hydrochloride salt Yield: 18 mg

Sources & evidence

ORD record
ord-960df21994aa4c69b213d01368bdb643
Source dataset
uspto-grants-2005_01
Patent number
US06844345B2

Reaction notes

Loading…