反应详情

Ethereal hydrogen chloride solution (1M, 1.5 ml) was added to a mixture of 5-amino-4,6-dichloropyrimidine (0.512 g), N-(3-amino-4-methylphenyl)-3-fluoro-5-morpholinobenzamide (0.514 g) and n-butanol (10 ml) and the resultant mixture was stirred and heated to reflux for 24 hours. Di-isopropylamine (1 ml) was added and the mixture was allowed to cool to ambient temperature. Water and a mixture of diethyl ether and isohexane were added and the precipitated solid was collected and dried. There was thus obtained the title compound (0.373 g); NMR Spectrum: 2.12 (s, 3H), 3.22 (m, 4H), 3.74 (m, 4H), 5.28 (s, 2H), 6.87 (d, 1H), 7.11 (d, 1H), 7.22 (d. 1H), 7.27 (s, 1H), 7.52 (d, 1H), 7.69 (s, 1H), 7.73 (s, 1H), 8.03 (s, 1H), 10.15 (s, 1H); Mass Spectrum: M−H − 455 & 457.

1. temperatureheated
2. temperatureto reflux for 24 hours
3. additionwere added
4. customthe precipitated solid was collected
5. customdried