2-Ethylhexanol → 2-(2-Ethylhexyloxy)-3-tert-butyl-1,3,2-oxazaphospholidine

HRID 1762294Notes

Reaction equation

HRID 1762294 reaction equation
[C:1]([N:5]1[CH2:9][CH2:8][O:7][P:6]1Cl)([CH3:4])([CH3:3])[CH3:2].C(N(CC)CC)C.[CH2:18]([CH:20]([CH2:23][CH2:24][CH2:25][CH3:26])[CH2:21][OH:22])[CH3:19]>C1COCC1>[CH2:18]([CH:20]([CH2:23][CH2:24][CH2:25][CH3:26])[CH2:21][O:22][P:6]1[N:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[CH2:9][CH2:8][O:7]1)[CH3:19]

Participants

5

Reactant 3

HCID 77202-EthylhexanolHCID 8471TriethylamineHCID 142281093-tert-Butyl-2-chloro-1,3,2-oxazaphospholidine

Product 1

HCID 200432052-(2-Ethylhexyloxy)-3-tert-butyl-1,3,2-oxazaphospholidineYield 81%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

The procedure of Example 3 is repeated using 18.16 g (0.10 mol) of 3-tert-butyl-2-chloro-1,3,2-oxazaphospholidine in 115 ml of THF and 13.16 ml (0.10 mol) of triethylamine and 13.2 g (0.10 mol) of 2-ethylhexanol in 115 ml of THF to give 22.3 g (81.0%) of a clear liquid: b.p. 89°-92° C. (0.05 mm Hg).

Sources & evidence

ORD record
ord-b84f5d07b5db43709e08cbce61a2d974
Source dataset
uspto-grants-1989_05
Patent number
US04831178

Reaction notes

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