Bromide ion → HCID 13747681, compound

HRID 1762536Notes

Reaction equation

HRID 1762536 reaction equation
[CH3:1]N1C2N=CNC=2C(=O)NC1=O.Cl[CH2:14][CH2:15][CH2:16][CH2:17][C:18]([OH:21])([CH3:20])[CH3:19].O=C(C)CCCC[N:28]1[C:37](=[O:38])[C:36]2[N:35]([CH2:39][CH2:40][CH2:41][CH2:42][C:43](=[O:45])[CH3:44])[CH:34]=[N:33][C:32]=2[N:31]([CH3:46])[C:29]1=[O:30].C[Mg]Cl.[Br-]>O1CCCC1>[OH:21][C:18]([CH3:20])([CH3:19])[CH2:17][CH2:16][CH2:15][CH2:14][N:28]1[C:37](=[O:38])[C:36]2[N:35]([CH2:39][CH2:40][CH2:41][CH2:42][C:43]([CH3:44])([OH:45])[CH3:1])[CH:34]=[N:33][C:32]=2[N:31]([CH3:46])[C:29]1=[O:30]

Participants

7

Reactant 5

HCID 259Bromide ionHCID 706393-MethylxanthineHCID 137476791-Chloro-5-hydroxy-5-methylhexaneHCID 153909313-Methyl-1,7-bis(5-oxohexyl)-3,7-dihydro-1H-purine-2,6-dioneHCID 178418332HCID 178418332, compound

Product 1

HCID 13747681HCID 13747681, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The same compound was also obtained, inter alia, by a one-stage dialkylation of 3-methylxanthine with twice the molar amount of 1-chloro-5-hydroxy-5-methylhexane or by reaction of 1,7-bis-(5-oxohexyl)-3-methylxanthine with two equivalents of methylmagnesium chloride or bromide in anhydrous tetrahydrofuran.

Workup

  1. customThe same compound was also obtained

Sources & evidence

ORD record
ord-80123447f4b14216b63d8c9fec5cc336
Source dataset
uspto-grants-1989_05
Patent number
US04833146

Reaction notes

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