Potassium Carbonate → HCID 13747688, compound

HRID 1762543Notes

Reaction equation

HRID 1762543 reaction equation
[CH3:1][N:2]1[C:10]2[N:9]=[CH:8][N:7]([CH2:11][C:12](=[O:14])[CH3:13])[C:6]=2[C:5](=[O:15])[NH:4][C:3]1=[O:16].Cl[CH2:18][CH2:19][CH2:20][CH2:21][C:22]([OH:25])([CH3:24])[CH3:23].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[OH:25][C:22]([CH3:24])([CH3:23])[CH2:21][CH2:20][CH2:19][CH2:18][N:4]1[C:5](=[O:15])[C:6]2[N:7]([CH2:11][C:12](=[O:14])[CH3:13])[CH:8]=[N:9][C:10]=2[N:2]([CH3:1])[C:3]1=[O:16]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 137476791-Chloro-5-hydroxy-5-methylhexaneHCID 13747686HCID 13747686, compound

Product 1

HCID 13747688HCID 13747688, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

22.2 g (0.1 mol) of the xanthine from stage (a) are reacted with 16.6 g (0.11 mol) of 1-chloro-5-hydroxy-5-methylhexane (Example 1a) and 15.2 g (0.11 mol) of potassium carbonate in 500 ml of dimethylformamide and the mixture is worked up, under the experimental conditions described in Example 2. The reaction product is purified by column chromatography and finally recrystallized from diisopropyl ether, with the addition of ethyl acetate, at the boiling point.

Workup

  1. customThe reaction product is purified by column chromatography
  2. customfinally recrystallized from diisopropyl ether, with the addition of ethyl acetate, at the boiling point

Sources & evidence

ORD record
ord-94b172c7c6e342999d2b059183c2707e
Source dataset
uspto-grants-1989_05
Patent number
US04833146

Reaction notes

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