Hydrochloric Acid → N-[2-(1-Benzofuran-3-yl)ethyl]formamide

HRID 1762972Notes

Reaction equation

HRID 1762972 reaction equation
[O:1]1[CH:5]=[C:4]([CH2:6][CH2:7][NH2:8])[C:3]2[CH:9]=[CH:10][CH:11]=[CH:12][C:2]1=2.Cl.[CH:14](OCC)=[O:15]>>[CH:14]([NH:8][CH2:7][CH2:6][C:4]1[C:3]2[CH:9]=[CH:10][CH:11]=[CH:12][C:2]=2[O:1][CH:5]=1)=[O:15]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 8025Ethyl formateHCID 124208122-Benzo[b]furan-3-ylethylamine

Product 1

HCID 13923851N-[2-(1-Benzofuran-3-yl)ethyl]formamide

Procedure

A solution of 121 g of 2-(3-benzo[b]furanyl)-ethylamine and 300 mL of ethyl formate was heated at 60° C. for 3 hours, poured into 2N HCl and washed with methylene chloride which in turn was washed with 5% sodium hydroxide (w/v), dried (Na2SO4), charcoaled and concentrated to give 118 g of product.

Workup

  1. washwashed with methylene chloride which in turn
  2. washwas washed with 5% sodium hydroxide (w/v)
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-9f4fdd9381e043b59fde473ab24256e6
Source dataset
uspto-grants-1989_05
Patent number
US04835276

Reaction notes

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