反应详情

温度

150 °C

To a solution of 22.1 g (0.1 mole) of 2-bromomethylnaphthalene in 150 ml of dimethylformamide, there were added successively 10.7 g (0.101 mole) of dry potassium carbonate and 17.2 g (0.101 mole) of 1-(2-thiazolyl)-piperazine. The resulting suspension was heated at 150° C. for 10 hours; the salt which had formed was then filtered off and the dimethylformamide was evaporated off under reduced pressure. There was obtained a brown crystalline residue which was washed with water and suction filtered off. The resulting 29 g of crystals were recrystallized in 150 ml of ethanol to give 20 g of 1-(2-naphthylmethyl)-4-(2-thiazolyl)-piperazine as beige crystals melting at 83°-84° C.

1. customthe salt which had formed
2. filtrationwas then filtered off
3. customthe dimethylformamide was evaporated off under reduced pressure
4. customThere was obtained a brown crystalline residue which
5. washwas washed with water and suction
6. filtrationfiltered off
7. customThe resulting 29 g of crystals were recrystallized in 150 ml of ethanol