1-Butanol → 3-(3-Chlorophenyl)-6-hydrazinylpyridazine

HRID 1763600Notes

Reaction equation

HRID 1763600 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([Cl:14])[CH:9]=2)=[CH:6][CH:7]=1.C(O)CCC.O.[NH2:21][NH2:22]>[N+](C)([O-])=O>[Cl:14][C:10]1[CH:9]=[C:8]([C:5]2[N:4]=[N:3][C:2]([NH:21][NH2:22])=[CH:7][CH:6]=2)[CH:13]=[CH:12][CH:11]=1

Participants

5

Reactant 3

HCID 2631-ButanolHCID 24654Hydrazine hydrate (1:1)HCID 127268113-Chloro-6-(3-chlorophenyl)pyridazine

Product 1

HCID 133889093-(3-Chlorophenyl)-6-hydrazinylpyridazine

Reagents, catalysts & solvents 1

HCID 6375NitromethaneSolvent

Procedure

A mixture of 6.85 g of 3-chloro-6-(m-chlorophenyl)pyridazine, 100 ml. of n-butanol and 3.05 g. of hydrazine hydrate is refluxed overnight. The solvent is removed under vacuum to give a semi-solid. The solid is dissolved in a minimum of hot nitromethane. Cooling gives 3.5 g. of amorphous solid.

Workup

  1. customThe solvent is removed under vacuum
  2. customto give a semi-solid
  3. temperatureCooling
  4. customgives 3.5 g

Sources & evidence

ORD record
ord-44d2a40e22344964a98de9946f60179e
Source dataset
uspto-grants-1978_09
Patent number
US04112095

Reaction notes

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