Triethylamine → HCID 20307399, compound

HRID 1763755Notes

Reaction equation

HRID 1763755 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][OH:5].C(N(CC)CC)C.[Cl:13][C:14]1[CH:19]=[C:18]([Cl:20])[CH:17]=[C:16]([Cl:21])[C:15]=1[S:22](Cl)(=[O:24])=[O:23]>O1CCCC1>[OH:5][CH2:4][CH2:3][CH2:2][NH:1][S:22]([C:15]1[C:16]([Cl:21])=[CH:17][C:18]([Cl:20])=[CH:19][C:14]=1[Cl:13])(=[O:24])=[O:23]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 90863-Amino-1-propanolHCID 5213352,4,6-Trichlorobenzenesulfonyl chloride

Product 1

HCID 20307399HCID 20307399, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To 40 parts of tetrahydrofuran are added 1.4 parts of 3-amino-1-propanol and 1.8 parts of triethylamine. Into this solution, 10 parts of tetrahydrofuran containing 5 parts of 2,4,6-trichlorobenzenesulfonyl chloride is dropped with stirring. After the dropping, the resultant mixture is stirred for 1 hour. After completion of the reaction, the salt is removed by filtration, and the filtrate is freed from the solvent. The resulting oily substance is charged with water and then allowed to stand to form a solid. This solid is recrystallized from toluene to obtain 3.8 parts of N-3-hydroxypropyl-2,4,6-trichlorobenzenesulfonamide, m.p. 104.5°-106.5° C.

Workup

  1. customAfter completion of the reaction
  2. customthe salt is removed by filtration
  3. additionThe resulting oily substance is charged with water
  4. customto form a solid
  5. customThis solid is recrystallized from toluene

Sources & evidence

ORD record
ord-17cf66319b71452c9b74863d51e55db1
Source dataset
uspto-grants-1978_09
Patent number
US04113463

Reaction notes

Loading…