Hydrochloric Acid → Phthalide

HRID 1764484Notes

Reaction equation

HRID 1764484 reaction equation
Cl[CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:4](=[O:5])[O:3]1.[H][H].Cl>[Pt].C1(C)C(C)=CC=CC=1>[C:4]1([C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[CH2:2][O:3]1)=[O:5]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 954693-ChlorophthalideHCID 178418361HCID 178418361, compound

Product 1

HCID 6885Phthalide

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 7237O-XyleneSolvent

Procedure

842.5 parts of 3-chlorophthalide and 750 parts of xylene were heated in a stirring vessel with 25.3 parts of a catalyst composed of 5% Pt on charcoal, at 85° C., and 160 liters of hydrogen were fed in hourly. After a reaction time of 13 hours, hydrogen chloride ceased to evolve. The reaction mixture was separated from the catalyst and worked up by distillation. 549 parts of phthalide were obtained, corresponding to 81.9% of the theory.

Workup

  1. customThe reaction mixture was separated from the catalyst
  2. distillationworked up by distillation

Sources & evidence

ORD record
ord-e2a29dbdb1134bb0b2e9ee3c8ea550a2
Source dataset
uspto-grants-1978_09
Patent number
US04116976

Reaction notes

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