Water → HCID 178525490, compound

HRID 1766176Notes

Reaction equation

HRID 1766176 reaction equation
[O:1]=[C:2]([C:9]1[CH:17]=[CH:16][C:12]2[NH:13][CH:14]=[N:15][C:11]=2[CH:10]=1)[CH2:3][CH2:4][C:5]([O:7]C)=[O:6].[OH-].[Li+].O>O1CCCC1>[O:1]=[C:2]([C:9]1[CH:17]=[CH:16][C:12]2[NH:13][CH:14]=[N:15][C:11]=2[CH:10]=1)[CH2:3][CH2:4][C:5]([OH:7])=[O:6]

Participants

5

Reactant 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 178500540HCID 178500540, compound

Product 1

HCID 178525490HCID 178525490, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared analogously to Example 5 from methyl γ-oxo-1H-benzimidazol-5-butanoate, lithium hydroxide and water in the presence of tetrahydrofuran in a yield of 78% of theoretical. Colourless crystals, m.p. 251–255° C. (decomp.).

Sources & evidence

ORD record
ord-b7696ed26cf84c32bff03f1bfed22645
Source dataset
uspto-grants-2007_06
Patent number
US07230001B1

Reaction notes

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