Lithium Hydroxide → Lithium 3-oxo-3-{[3-(trifluoromethyl)phenyl]amino}propanoate

HRID 1766358Notes

Reaction equation

HRID 1766358 reaction equation
O1CCCC1.[O:6]=[C:7]([NH:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:16]=1)[CH2:8][C:9]([O:11]CC)=[O:10].[OH-].[Li+:26]>O>[O:6]=[C:7]([NH:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:22])([F:23])[F:24])[CH:16]=1)[CH2:8][C:9]([O-:11])=[O:10].[Li+:26]

Participants

5

Reactant 3

HCID 3939Lithium HydroxideHCID 8028TetrahydrofuranHCID 3651864Ethyl 3-oxo-3-{[3-(trifluoromethyl)phenyl]amino}propanoate

Product 1

HCID 23693664Lithium 3-oxo-3-{[3-(trifluoromethyl)phenyl]amino}propanoate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a tetrahydrofuran (350 ml) solution of Example 34A (5 g, 18.17 mmol) is added lithium hydroxide (435 mg, 18.17 mmol) in water (150 ml). The solution is stirred at room temperature for 4 hours, and then concentrated to afford a white solid. The product is used without further purification.

Workup

  1. concentrationconcentrated
  2. customto afford a white solid
  3. customThe product is used without further purification

Sources & evidence

ORD record
ord-fdbeea153b3e4824a69694aedf50e267
Source dataset
uspto-grants-2007_06
Patent number
US07230017B2

Reaction notes

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