反应详情

N-methylmorpholine (1.01 g, 10 mmol) was added to 2-(2-nitro-1H-imidazol-1-yl)-acetic acid (1.71 g, 10 mmol) in 150 mL of dry THF under nitrogen at 0° C. and stirred for 10 minutes. Isobutyl chloroformate (1.43 mL, 11 mmol) was added. After 30 minutes, 2-fluoro allyl amine hydrochloride (1.23 g, 11 mmol) and N-methylmorpholine (1.21 g, 12 mmol) was added to the solution and the mixture was stirred at room temperature overnight. The solution was filtered and the organic solvent evaporated to give a yellow solid. Purified by column afforded a light yellow solid (1.1 g, 50%).

1. waitAfter 30 minutes
2. stirringthe mixture was stirred at room temperature overnight
3. filtrationThe solution was filtered
4. customthe organic solvent evaporated
5. customto give a yellow solid
6. customPurified by column