反应详情

A solution of 4-(2-nitrovinyl)indole (II) (3 g, 15.9 mmol) in THF (10 ml) was added to a suspension of DIBAH (1M THF, 159 ml, 159 mmol) under an inert atmosphere and was stirred at room temperature for 30 min, then it was heated at 60° C. and stirred for 5 hours. The obtained mixture was cooled to 0° C., AcOEt, water and KOH 10% were added and the ontained product was filtered. The aqueous layer was extracted with AcOEt and the organic layer was dried and evaporated to obtain 4-[(2-amino)ethyl]indole (III).

1. temperatureit was heated at 60° C.
2. stirringstirred for 5 hours
3. temperatureThe obtained mixture was cooled to 0° C.
4. filtrationthe ontained product was filtered
5. extractionThe aqueous layer was extracted with AcOEt
6. customthe organic layer was dried
7. customevaporated