反应详情

A solution of 706 mg (5.06 mmol) triphenylchloromethane in 5.0 ml DMF was added at 0° C. to a solution of 500 mg (2.30 mmol) 4-(4-1H-[1,2,3]triazol-4-yl-butyl)-phenol and 512 mg (5.06 mmol) triethylamine in 5.0 ml DMF. The mixture was allowed to reach r.t. overnight and solvents were removed in vacuo. After distribution of the residue between water and ethyl acetate, the organic phase was dried (sodium sulphate), solvents distilled off and the residue purified by column chromatography on silica gel (heptane/ethyl acetate 2:1).

1. customsolvents were removed in vacuo
2. dry with materialAfter distribution of the residue between water and ethyl acetate, the organic phase was dried (sodium sulphate), solvents
3. distillationdistilled off
4. customthe residue purified by column chromatography on silica gel (heptane/ethyl acetate 2:1)