Tetrahydrofuran → HCID 11710114, compound

HRID 1768444Notes

Reaction equation

HRID 1768444 reaction equation
[C:1]1([P:7]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)([CH:9]2[CH2:14][CH:13]3[CH2:15][C@H:11]([C:12]3([CH3:17])[CH3:16])[C:10]2=[CH2:18])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1C[O:28]CC1>B1C2CCCC1CCC2>[C:1]1([P:7]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)([C@@H:9]2[CH2:14][CH:13]3[CH2:15][CH:11]([C:12]3([CH3:16])[CH3:17])[C@@H:10]2[CH2:18][OH:28])=[O:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 8028TetrahydrofuranHCID 69411198HCID 69411198, compound

Product 1

HCID 11710114HCID 11710114, compound

Reagents, catalysts & solvents 1

HCID 789669-Borabicyclo(3.3.1)nonaneSolvent

Conditions

Temperature
70 °C

Procedure

8.0 g (20 mmol) of phosphine oxide (9) were dissolved under an argon atmosphere in 50 ml of 0.5 M THF solution of 9-BBN (Aldrich) and the reaction mixture was heated to 70° C. in a closed reaction vessel for 12 h.

Sources & evidence

ORD record
ord-82ee6497930e47c2a7fc3dec1e0dceda
Source dataset
uspto-grants-2007_06
Patent number
US07235696B2

Reaction notes

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