反应详情

8.17 g (0.19 mole) of sodium hydride (as a 55% w/w dispersion in mineral oil) were added, with ice-cooling, to a solution of 25 g (0.16 mole) of dimethyl glutarate and 23.4 g (0.16 mole) of 1-naphthaldehyde dissolved in 200 ml of anhydrous methanol. The mixture was heated under reflux for 30 minutes, after which 190 ml (0.19 mole) of a 1N aqueous solution of sodium hydroxide were added and the mixture was heated under reflux for a further 1 hour. The solvent was then removed by distillation under reduced pressure, and the residue was mixed with water and then washed with diethyl ether. The aqueous layer was acidified and extracted with diethyl ether. The ethereal layer was washed with a saturated aqueous solution of sodium chloride and then dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure, and then diisopropyl ether was added to the residue to precipitate crystals, which were collected by filtration to give 18.5 g of 2-(1 -naphthylmethylene)glutaric acid.

1. temperatureThe mixture was heated
2. temperatureunder reflux for 30 minutes
3. temperaturethe mixture was heated
4. temperatureunder reflux for a further 1 hour
5. customThe solvent was then removed by distillation under reduced pressure
6. additionthe residue was mixed with water
7. washwashed with diethyl ether
8. extractionextracted with diethyl ether
9. washThe ethereal layer was washed with a saturated aqueous solution of sodium chloride
10. dry with materialdried over anhydrous magnesium sulfate
11. customThe solvent was removed by distillation under reduced pressure
12. additiondiisopropyl ether was added to the residue
13. customto precipitate crystals, which
14. filtrationwere collected by filtration