3-Hydroxybenzaldehyde → Benzaldehyde, 3-(2-hydroxyethoxy)-

HRID 1768608Notes

Reaction equation

HRID 1768608 reaction equation
[Na].[OH:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH:6]=[O:7].Br[CH:12]([OH:14])[CH3:13]>C(O)C>[OH:14][CH2:12][CH2:13][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH:6]=[O:7]

Participants

5

Reactant 3

HCID 1013-HydroxybenzaldehydeHCID 5360545SodiumHCID 14202443Ethanol, 1-bromo-

Product 1

HCID 6453965Benzaldehyde, 3-(2-hydroxyethoxy)-

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.42 g of sodium were dissolved in 200 ml of ethanol. 7.5 g of 3-hydroxybenzaldehyde and 10.5 g of bromoethanol were added and the resulting solution was refluxed for 5 hours. The solution was purified by column chromatography (silica, CH2Cl2).

Workup

  1. temperaturethe resulting solution was refluxed for 5 hours
  2. customThe solution was purified by column chromatography (silica, CH2Cl2)

Sources & evidence

ORD record
ord-c45f1b75c2e1437fa0065d8d13b3d929
Source dataset
uspto-grants-1995_01
Patent number
US05378718

Reaction notes

Loading…