Hydrochloric Acid → HCID 18949407, compound

HRID 1768742Notes

Reaction equation

HRID 1768742 reaction equation
[NH2:1][C:2]1([C:7]2[NH:15][C:14]3[C:13](=[O:16])[N:12]([CH2:17][CH2:18][CH3:19])[C:11](=[O:20])[N:10]([CH2:21][CH2:22][CH3:23])[C:9]=3[N:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3]1.N1C=CC=CC=1.Cl.[C:31]([O:34][CH2:35][CH3:36])(=[O:33])C>O1CCCC1>[CH2:17]([N:12]1[C:13](=[O:16])[C:14]2[NH:15][C:7]([C:2]3([NH:1][C:31]([O:34][CH2:35][CH3:36])=[O:33])[CH2:3][CH2:4][CH2:5][CH2:6]3)=[N:8][C:9]=2[N:10]([CH2:21][CH2:22][CH3:23])[C:11]1=[O:20])[CH2:18][CH3:19]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 1049PyridineHCID 8857Ethyl AcetateHCID 3047747Midaxifylline

Product 1

HCID 18949407HCID 18949407, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a suspension of 4.5 g of 8-(1-aminocyclopentyl)-1,3-dipropylxanthine in 45 ml of anhydrous tetrahydrofurane 1.83 ml of pyridine and 1.97 ml of ethyl chloroformiate are added. The mixture is stirred for 2 hours at room temperature, followed by the addition of 1N HCl and extraction with ethyl acetate. The organic phase is washed with water, dried and evaporated to obtain 4.2 g of raw product, which is finally crystallized from ethanol/water.

Workup

  1. additionare added
  2. washThe organic phase is washed with water
  3. customdried
  4. customevaporated

Sources & evidence

ORD record
ord-9ae5689abff34f3e9ef687a343eb5b79
Source dataset
uspto-grants-1995_01
Patent number
US05378844

Reaction notes

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