HRID1769376

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID77637

Cyclopropanecarbonyl chloride

C4H5ClO

HCID5360545

Sodium

结构：COC(=O)C(C)(C)Cc1cc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(Cl)cc1

HCID9892642

未命名化合物

PRODUCTS

生成物

结构：CC(C)(Cc1c(C(=O)C2CC2)c2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(Cl)cc1)C(=O)O

HCID18947627

未命名化合物

PROCEDURE

实验过程

The title compound was prepared according to the conditions described in Step B and Step C of Example 47, from methyl 3-[N-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoate (prepared in Step A of Example 47), but using cyclopropanecarbonyl chloride in place of trimethylacetyl chloride in Step B. Anal. C, H, N for sodium salt·1 H2O: Calc. C 67.27; H 5.31; N 4.61 Found C 67.27; H 5.16; N. 4.58.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-026e676201ae433696b4666423d87a5a
来源数据集: uspto-grants-1995_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05380850
来源说明: uspto-grants-1995_01

反应 SMILES

[Cl:1][C:2]1[CH:37]=[CH:36][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([O:16][CH2:17][C:18]4[CH:27]=[CH:26][C:25]5[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=5)[N:19]=4)=[CH:13][CH:14]=3)[CH:9]=[C:8]2[CH2:28][C:29]([CH3:35])([CH3:34])[C:30]([O:32]C)=[O:31])=[CH:4][CH:3]=1.[CH:38]1([C:41](Cl)=[O:42])[CH2:40][CH2:39]1.[Na]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([O:16][CH2:17][C:18]4[CH:27]=[CH:26][C:25]5[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=5)[N:19]=4)=[CH:13][CH:14]=3)[C:9]([C:41]([CH:38]3[CH2:40][CH2:39]3)=[O:42])=[C:8]2[CH2:28][C:29]([CH3:34])([CH3:35])[C:30]([OH:32])=[O:31])=[CH:36][CH:37]=1