Hydrochloric Acid → HCID 3596801, compound

HRID 1770060Notes

Reaction equation

HRID 1770060 reaction equation
[CH:1]1([NH2:8])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C([N:11]([CH2:14][CH3:15])CC)C.[C:16](Cl)(=[O:26])[C:17]1[CH:25]=[CH:24][CH:23]=[C:19]([C:20](Cl)=[O:21])[CH:18]=1.Cl>C(Cl)Cl.O>[CH:1]1([NH:8][C:16](=[O:26])[C:17]2[CH:25]=[CH:24][CH:23]=[C:19]([C:20]([NH:11][CH:14]3[CH2:15][CH2:6][CH2:7][CH2:1][CH2:2][CH2:3]3)=[O:21])[CH:18]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 2899CycloheptylamineHCID 7451Isophthaloyl chlorideHCID 8471Triethylamine

Product 1

HCID 3596801HCID 3596801, compoundYield 96.1%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6344DichloromethaneSolvent

Procedure

20.8 g of cycloheptylamine and 20.25 g of triethylamine were dissolved in 500 ml of methylenechloride, and then, 17.0 g of iso-phthaloyl chloride was added to thereto. The mixture was stirred at room temperature for 2 hours, and 500 ml of water was added to the reaction mixture. Then, conc. HCl was added thereto while stirring. Precipitated soli material was collected by filtration, washed with methylene chloride and water successively, and dried giving 28.7 g of N,N'-dicycloheptylisophthalamide.

Workup

  1. stirringwhile stirring
  2. filtrationPrecipitated soli material was collected by filtration
  3. washwashed with methylene chloride and water successively
  4. customdried

Sources & evidence

ORD record
ord-0493bf98bd0244b9a0b18ee62290b534
Source dataset
uspto-grants-1995_01
Patent number
US05384425

Reaction notes

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