Potassium Iodide → 8-Azaspiro(4.5)decane-7,9-dione, 8-(4-((3,4-dihydro-2H-1-benzothiopyran-8-yl)oxy)butyl)-

HRID 1770217Notes

Reaction equation

HRID 1770217 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:15](=[O:16])[CH2:14][C:9]2([CH2:13][CH2:12][CH2:11][CH2:10]2)[CH2:8][C:7]1=[O:17].C(=O)([O-])[O-].[K+].[K+].[I-].[K+].[S:26]1[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][C:34]=2[OH:36])[CH2:29][CH2:28][CH2:27]1>CN(C)C=O>[O:16]=[C:15]1[N:6]([CH2:5][CH2:4][CH2:3][CH2:2][O:36][C:34]2[CH:33]=[CH:32][CH:31]=[C:30]3[C:35]=2[S:26][CH2:27][CH2:28][CH2:29]3)[C:7](=[O:17])[CH2:8][C:9]2([CH2:13][CH2:12][CH2:11][CH2:10]2)[CH2:14]1

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 1216173,4-dihydro-2H-1-benzothiopyran-8-olHCID 112088518-(4-Bromobutyl)-8-azaspiro(4.5)decane-7,9-dione

Product 1

HCID 30739058-Azaspiro(4.5)decane-7,9-dione, 8-(4-((3,4-dihydro-2H-1-benzothiopyran-8-yl)oxy)butyl)-

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2 g (6.62 mmol) of 8-(4-bromobutyl)-8-azaspiro[4.5]decane-7,9-dione, 2.5 g (18.04 mmol) of potassium carbonate and a catalytic amount of potassium iodide are added, with stirring, to 1 g (6.015 mmol) of 8-thiochromanol dissolved in 10 cm3 of N,N-dimethylformamide.

Sources & evidence

ORD record
ord-bf64e2c4e38c42e781772b7fefc821ac
Source dataset
uspto-grants-1995_01
Patent number
US05385930

Reaction notes

Loading…