Triethylamine → 2-(7-Methoxynaphthalen-1-yl)acetonitrile

HRID 1770230Notes

Reaction equation

HRID 1770230 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[C:10]2[CH2:13][C:14]([NH2:16])=O)=[CH:5][CH:4]=1.C(N(CC)CC)C.FC(F)(F)C(OC(=O)C(F)(F)F)=O>O1CCCC1>[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[C:10]2[CH2:13][C:14]#[N:16])=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 9845Trifluoroacetic anhydrideHCID 151491272-(7-Methoxynaphthalen-1-yl)acetamide

Product 1

HCID 112640682-(7-Methoxynaphthalen-1-yl)acetonitrile

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The (7-methoxynaphth-1-yl)acetamide obtained in step E is suspended in 80 cm3 of anhydrous tetrahydrofuran. Triethylamine is added. The solution is cooled in an ice bath, and then trifluoroacetic anhydride is added dropwise, with magnetic stirring.

Workup

  1. temperatureThe solution is cooled in an ice bath

Sources & evidence

ORD record
ord-6a4a261f043846a6bb48d7baba278760
Source dataset
uspto-grants-1995_01
Patent number
US05385944

Reaction notes

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