反应详情

The product of Example 42 (2.4 g, 8 mmol) was dissolved in N,N-dimethylformamide, potassium carbonate (2.7 g, 20 mmol) and dimethylamine hydrochloride (0.7 g, 8 mmol) were added therein, then it was reacted at room temperature for 12 hours. After that, the reaction solution was poured into water, the aqueous phase was extracted with dichloromethane twice, then the organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, concentrated, and separated through silica gel column chromatography to give target 2.2 g, yield: 90%.

1. customit was reacted at room temperature for 12 hours
2. extractionthe aqueous phase was extracted with dichloromethane twice
3. washwashed with saturated brine
4. dry with materialdried over anhydrous sodium sulfate
5. concentrationconcentrated
6. customseparated through silica gel column chromatography
7. customto give