反应详情

温度

0 °C

To a solution of 2,4-dichloropyrimidine (5.00 g, 0.034 mol) and DIPEA (8.00 mL, 0.046 mol) in 2-propanol (60 mL) at 0° C. was added (S)-3-methylmorpholine (3.73 g, 0.037 mol) dropwise. The reaction mixture was stirred at 0° C. for 30 min and then allowed to warm to RT and stirred for a further 16 h. Solvent was removed in vacuo and the residue was then partitioned between water and EtOAc. The phases were separated and the organic layer washed with brine, dried over magnesium sulfate, filtered and the solvent removed in vacuo to yield a yellow oil (6.54 g, 91%).

1. temperatureto warm to RT
2. stirringstirred for a further 16 h
3. customSolvent was removed in vacuo
4. customthe residue was then partitioned between water and EtOAc
5. customThe phases were separated
6. washthe organic layer washed with brine
7. dry with materialdried over magnesium sulfate
8. filtrationfiltered
9. customthe solvent removed in vacuo