Hydrochloric Acid → HCID 59376826, compound

HRID 1771867Notes

Reaction equation

HRID 1771867 reaction equation
[CH:1]([C:4]1[CH:5]=[CH:6][C:7]2[C:12]([NH:13][C:14]3[CH:15]=[C:16]([CH:21]=[CH:22][CH:23]=3)[C:17]([O:19]C)=[O:18])=[N:11][CH:10]=[N:9][C:8]=2[N:24]=1)([CH3:3])[CH3:2].O.[Li+].[OH-].Cl>C1COCC1>[CH:1]([C:4]1[CH:5]=[CH:6][C:7]2[C:12]([NH:13][C:14]3[CH:15]=[C:16]([CH:21]=[CH:22][CH:23]=3)[C:17]([OH:19])=[O:18])=[N:11][CH:10]=[N:9][C:8]=2[N:24]=1)([CH3:3])[CH3:2]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 3939Lithium HydroxideHCID 59376777HCID 59376777, compound

Product 1

HCID 59376826HCID 59376826, compoundYield 149.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The product from Example 7A (1.0 g, 3.26 mmol) was dissolved in THF (12.0 mL) and water (12.0 mL) and LiOH (390 mg, 16.29 mmol) was added and the reaction was stirred at room temperature overnight. Reaction was neutralised with 1 N HCl and extracted with ethyl acetate. Dried over Na2SO4, filtered and concentrated to give the title compound (1.5 g).

Workup

  1. customReaction
  2. extractionextracted with ethyl acetate
  3. dry with materialDried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-da8888c11dc94ac99c6bc00a7390cf14
Source dataset
uspto-grants-2016_02
Patent number
US09249138B2

Reaction notes

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