反应详情

温度

60 °C

To 25 mL round bottom flask charged with ester 101h (100 mg, 0.16 mmol) and LiOH (20 mg, 0.47 mmol) in THF (2 mL), EtOH (2 mL) and H2O (2 mL). After the mixture was stirred at 60° C. for 16 h, the pH was adjusted to 7 with aqueous 1M HCl. The aqueous phase was extracted with EtOAc (2×10 mL), and the combined organic extracts were washed with brine (10 mL), dried with Na2SO4 and concentrated. The crude 101i (97 mg, 99%) was used without further purification.

1. extractionThe aqueous phase was extracted with EtOAc (2×10 mL)
2. washthe combined organic extracts were washed with brine (10 mL)
3. dry with materialdried with Na2SO4
4. concentrationconcentrated
5. customThe crude 101i (97 mg, 99%) was used without further purification