反应详情

To a solution of compound 15b (500 mg, 0.960 mmol) in THF (20 mL) was added a solution of LiOH (100 mg, 4.18 mmol) in H2O (5 mL). The resulting solution was stirred at rt overnight, and then diluted with H2O (20 mL). The pH of the solution was adjusted to 3 with 2 N HCl solution. The resulting solids were collected by filtration and washed with Et2O to obtain compound 15c as a yellow solid (350 mg, 72% yield). Mass Spectrum (LCMS, ESI pos.): Calcd. for C28H23N9O2: 482.2 (M+H). Found 482.0.

1. filtrationThe resulting solids were collected by filtration
2. washwashed with Et2O