Potassium Carbonate → HCID 90054927, compound

HRID 1772987Notes

Reaction equation

HRID 1772987 reaction equation
ClC1C=CN=CC=1S(NC1C=CC(OC)=C(OC)C=1)(=O)=O.[F:22][C:23]1[CH:30]=[C:29]([Cl:31])[CH:28]=[CH:27][C:24]=1[CH2:25][NH2:26].C([O-])([O-])=O.[K+].[K+].C(N1C=CN=C1)(N1C=CN=C1)=O.ClC1C=CC=C(F)C=1CN1[C:59]2[CH:60]=[CH:61][N:62]=[CH:63][C:58]=2[S:57](=[O:65])(=[O:64])[N:56]([C:66]2[CH:71]=[CH:70][C:69]([O:72][CH3:73])=[C:68]([O:74][CH3:75])[CH:67]=2)[C:55]1=[O:76]>>[Cl:31][C:29]1[CH:28]=[CH:27][C:24]([CH2:25][N:26]2[C:59]3[CH:60]=[CH:61][N:62]=[CH:63][C:58]=3[S:57](=[O:65])(=[O:64])[N:56]([C:66]3[CH:71]=[CH:70][C:69]([O:72][CH3:73])=[C:68]([O:74][CH3:75])[CH:67]=3)[C:55]2=[O:76])=[C:23]([F:22])[CH:30]=1

Participants

6

Reactant 5

HCID 11430Potassium CarbonateHCID 682631,1'-CarbonyldiimidazoleHCID 27249104-Chloro-2-fluorobenzylamineHCID 64280908HCID 64280908, compoundHCID 90054926HCID 90054926, compound

Product 1

HCID 90054927HCID 90054927, compound

Procedure

The title compound (110 mg, 0.23 mmol) was prepared in two steps from 4-Chloro-N-(3,4-dimethoxyphenyl)pyridine-3-sulfonamide (IntD1) (300 mg, 0.90 mmol), 2-fluoro-4-chlorobenzylamine (146 mg, 0.90 mmol) and K2CO3 (378 mg, 2.73 mmol); followed by 1,1′-carbonyldiimidazole (0.22 g, 1.32 mmol) using the methods of (91).

Sources & evidence

ORD record
ord-c5f15a6ffa724353b1ce00458ca34eac
Source dataset
uspto-grants-2016_02
Patent number
US09249160B2

Reaction notes

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