Potassium Carbonate → HCID 90054673, compound

HRID 1772992Notes

Reaction equation

HRID 1772992 reaction equation
Cl[CH2:2][C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]([CH3:12])[N:4]=1.C([O-])([O-])=O.[K+].[K+].[F:19][C:20]1[CH:48]=[CH:47][CH:46]=[C:45]([F:49])[C:21]=1[CH2:22][N:23]1[C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=2[S:26](=[O:34])(=[O:33])[N:25](CCC2C(C)=NOC=2C)[C:24]1=[O:44]>CN(C=O)C>[F:19][C:20]1[CH:48]=[CH:47][CH:46]=[C:45]([F:49])[C:21]=1[CH2:22][N:23]1[C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=2[S:26](=[O:34])(=[O:33])[N:25]([CH2:2][C:3]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]([CH3:12])[N:4]=2)[C:24]1=[O:44]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 75374703-(chloromethyl)-1-methyl-1H-indazoleHCID 90055068HCID 90055068, compound

Product 1

HCID 90054673HCID 90054673, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound (11 mg, 0.02 mmol) was prepared from (IntE3) (50 mg, 0.154 mmol), 3-(chloromethyl)-1-methyl-1H-indazole (69.6 mg, 0.39 mmol), KI (5.1 mg, 0.03 mmol) and K2CO3 (53.3 mg, 0.39 mmol) in DMF (3 mL) in a CEM Discover microwave reactor (100° C., 1 h) using the methods of (120).

Sources & evidence

ORD record
ord-f901303b7d61486baa9fb92b86370b1a
Source dataset
uspto-grants-2016_02
Patent number
US09249160B2

Reaction notes

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