Potassium Carbonate → HCID 90055164, compound

HRID 1772993Notes

Reaction equation

HRID 1772993 reaction equation
Cl.Cl[CH:3]1[CH2:8][CH2:7][CH2:6][N:5]([CH2:9][CH3:10])[CH2:4]1.C([O-])([O-])=O.[K+].[K+].[F:17][C:18]1[CH:46]=[CH:45][CH:44]=[C:43]([F:47])[C:19]=1[CH2:20][N:21]1[C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=2[S:24](=[O:32])(=[O:31])[N:23](CCC2C(C)=NOC=2C)[C:22]1=[O:42]>CN(C=O)C>[F:17][C:18]1[CH:46]=[CH:45][CH:44]=[C:43]([F:47])[C:19]=1[CH2:20][N:21]1[C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=2[S:24](=[O:32])(=[O:31])[N:23]([CH:3]2[CH2:8][CH2:7][CH2:6][N:5]([CH2:9][CH3:10])[CH2:4]2)[C:22]1=[O:42]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 308492250461-27-3HCID 90055068HCID 90055068, compound

Product 1

HCID 90055164HCID 90055164, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound (42 mg, 0.09 mmol) was prepared from (IntE3) (100 mg, 0.31 mmol), 3-chloro-1-ethylpiperidine hydrochloride (142 mg, 0.77 mmol), KI (10.2 mg, 0.06 mmol) and K2CO3 (107 mg, 0.77 mmol) in DMF (5 mL) in a CEM Discover microwave reactor (100° C., 1 h) using the methods of (120).

Sources & evidence

ORD record
ord-3804313302cb478e8f11bd1e8a5b728b
Source dataset
uspto-grants-2016_02
Patent number
US09249160B2

Reaction notes

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