反应详情

A mixture of methyl 2-bromo-3-(3-oxocyclohex-1-enylamino)benzoate (0.97 g, 3.0 mmol), palladium acetate (0.14 g, 0.6 mmol), tri-o-tolylphosphine (0.73 g, 2.4 mmol), and triethylamine (0.38 g, 3.6 mmol) in acetonitrile (10 mL) was heated in a sealed tubule flushed with nitrogen at 100° C. for 20 h. The cooled reaction mixture was diluted with DCM (3×50 mL) and water (10 mL). The organic layer was separated, washed with water, dried (Na2SO4), and concentrated.

1. temperaturewas heated in a sealed
2. customtubule flushed with nitrogen at 100° C. for 20 h
3. customThe cooled reaction mixture
4. customThe organic layer was separated
5. washwashed with water
6. dry with materialdried (Na2SO4)
7. concentrationconcentrated