Hydrochloric Acid → HCID 86679495, compound

HRID 1776538Notes

Reaction equation

HRID 1776538 reaction equation
[Cl:1][C:2]1[CH:3]=[N+:4]([O-:54])[CH:5]=[C:6]([Cl:53])[C:7]=1[CH2:8][C@@H:9]([C:38]1[CH:43]=[CH:42][C:41]([O:44][CH:45]([F:47])[F:46])=[C:40]([O:48][CH2:49][CH:50]2[CH2:52][CH2:51]2)[CH:39]=1)[O:10][C:11](=[O:37])[CH2:12][O:13][C:14](=[O:36])[C:15]1[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[C:17]([N:23]([CH2:28][CH2:29][N:30]2[CH2:35][CH2:34][O:33][CH2:32][CH2:31]2)[S:24]([CH3:27])(=[O:26])=[O:25])[CH:16]=1.Cl>CCOC(C)=O.CCOCC>[ClH:1].[Cl:1][C:2]1[CH:3]=[N+:4]([O-:54])[CH:5]=[C:6]([Cl:53])[C:7]=1[CH2:8][C@@H:9]([C:38]1[CH:43]=[CH:42][C:41]([O:44][CH:45]([F:46])[F:47])=[C:40]([O:48][CH2:49][CH:50]2[CH2:52][CH2:51]2)[CH:39]=1)[O:10][C:11](=[O:37])[CH2:12][O:13][C:14](=[O:36])[C:15]1[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[C:17]([N:23]([CH2:28][CH2:29][N:30]2[CH2:31][CH2:32][O:33][CH2:34][CH2:35]2)[S:24]([CH3:27])(=[O:26])=[O:25])[CH:16]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 71543203HCID 71543203, compound

Product 1

HCID 86679495HCID 86679495, compoundYield 125.9%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolvent2×HCID 8857Ethyl AcetateSolvent

Procedure

(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)benzoyloxy)-acetoxy)ethyl)pyridine 1-oxide (21 mg, 0.026 mmol) was dissolved in EtOAc (1 ml). HCl 2M in Et2O (15 μl) was added, then Et2O (5 ml) was added. The precipitate was filtered and dried in the vacuum oven to give 14 mg of final product.

Workup

  1. filtrationThe precipitate was filtered
  2. customdried in the vacuum oven

Sources & evidence

ORD record
ord-b3ce2463c6a541078ab069faec2ec453
Source dataset
uspto-grants-2016_02
Patent number
US09265768B2

Reaction notes

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