3-Amino-1-propanol → HCID 118201023, compound

HRID 1777374Notes

Reaction equation

HRID 1777374 reaction equation
[C:1]([O:5][CH2:6][CH3:7])(=[O:4])[CH:2]=[O:3].[NH2:8][CH2:9][CH2:10][CH2:11]O.[CH3:13][C:14]1[CH:15]=[CH:16][C:17]([N:23]2[N:27]=[CH:26][CH:25]=[N:24]2)=[C:18]([CH:22]=1)[C:19]([OH:21])=O>C1(C)C=CC=CC=1>[CH3:13][C:14]1[CH:15]=[CH:16][C:17]([N:23]2[N:27]=[CH:26][CH:25]=[N:24]2)=[C:18]([CH:22]=1)[C:19]([N:8]1[CH2:9][CH2:10][CH2:11][O:3][CH:2]1[C:1]([O:5][CH2:6][CH3:7])=[O:4])=[O:21]

Participants

5

Reactant 3

HCID 90863-Amino-1-propanolHCID 70211Ethyl oxoacetateHCID 532601655-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid

Product 1

HCID 118201023HCID 118201023, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

By using ethyl glyoxylate (polymer type, a solution of 47% toluene) (4.3 mL, 20.4 mol), 3-aminopropan-1-ol (1.6 mL, 20.4 mmol) and 5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid (1.0 g, 4.9 mmol), the same procedure as in Reference Example 1 was carried out to obtain the title compound (1.3 g) (colorless solid).

Sources & evidence

ORD record
ord-17c557de0355419e8f818c38449ea325
Source dataset
uspto-grants-2016_02
Patent number
US09266870B2

Reaction notes

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