Ammonium Chloride → HCID 10406441, compound

HRID 1777404Notes

Reaction equation

HRID 1777404 reaction equation
[F:1][C:2]([F:27])([F:26])[C:3]1[CH:4]=[C:5]([NH:13][C:14](=[O:25])[C:15]2[CH:20]=[C:19]([N+:21]([O-])=O)[CH:18]=[CH:17][C:16]=2[OH:24])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[NH4+].[Cl-]>[Fe].C(O)(C)C>[NH2:21][C:19]1[CH:18]=[CH:17][C:16]([OH:24])=[C:15]([CH:20]=1)[C:14]([NH:13][C:5]1[CH:6]=[C:7]([C:9]([F:10])([F:11])[F:12])[CH:8]=[C:3]([C:2]([F:1])([F:26])[F:27])[CH:4]=1)=[O:25]

Participants

5

Reactant 2

HCID 25517Ammonium ChlorideHCID 11741321N-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-5-nitro-benzamide

Product 1

HCID 10406441HCID 10406441, compound

Reagents, catalysts & solvents 2

HCID 23925IronCatalystHCID 3776IsopropanolSolvent

Procedure

N-(3,5-bis-trifluoromethyl-phenyl)-2-hydroxy-5-nitro-benzamide (400 mg, 1.4 mmol) prepared in step 1 was dissolved in 4.2 . of isopropanol (IPA), to which 3 g of iron powder and 3 . of NH4Cl saturated solution were added.

Sources & evidence

ORD record
ord-e35eed8f7f2748c9a78cee72ca3d21d3
Source dataset
uspto-grants-2016_02
Patent number
US09266872B2

Reaction notes

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