反应详情

温度

100 °C

A mixture of 6-bromo-1-isopropyl-1H-imidazo[4,5-c]pyridine (intermediate 256, 2.134 g, 8.80 mmol), 4-methoxybenzylamine (1.389 ml, 10.38 mmol), NaOt-Bu (1.308 g, 13.20 mmol), Pd(OAc)2 (0.14 g, 0.616 mmol) and Xantphos (0.367 g, 0.616 mmol) in toluene (90 ml) was evacuated and purged with argon (3×) and then heated to 100° C. After 17 h, the reaction mixture was quenched with H2O and extracted with EtOAc (3×). The combined organic layers were washed with brine, dried over

1. customwas evacuated
2. custompurged with argon (3×)
3. customthe reaction mixture was quenched with H2O
4. extractionextracted with EtOAc (3×)
5. washThe combined organic layers were washed with brine
6. customdried over