Hydrochloric Acid → HCID 89498001, compound

HRID 1778843Notes

Reaction equation

HRID 1778843 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][N:5]([CH:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:8][CH:9](OC)[O:10]C)[CH:6]=1.Cl>O1CCCC1>[Br:1][C:2]1[CH:3]=[N:4][N:5]([CH:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:8][CH:9]=[O:10])[CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 89498369HCID 89498369, compound

Product 1

HCID 89498001HCID 89498001, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of EXAMPLE 77B (0.34 g) and hydrochloric acid (2 mL) in tetrahydrofuran (3.5 mL) was stirred at room temperature for 16 hours. The reaction mixture was concentrated, redissolved in dichloromethane, dried over magnesium sulfate, filtered, and used in the next step without purification.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. dissolutionredissolved in dichloromethane
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. customused in the next step without purification

Sources & evidence

ORD record
ord-9d9b962fcfc2432b8fa725e31fb559fb
Source dataset
uspto-grants-2016_02
Patent number
US09266877B2

Reaction notes

Loading…