反应详情

A mixture of EXAMPLE 163A (400 mg), benzotriazol-1-yloxytripyrrolidinophosphonium hexafluorophosphate (714 mg), triethylamine (0.383 mL) and benzo[d]thiazol-2-amine (247 mg) in dichloromethane (10 mL) was stirred overnight at room temperature. The mixture was diluted with ethyl acetate (100 mL), washed with brine (30 mL×3), dried over Na2SO4, filtered, concentrated and purified by flash chromotography (silica gel, petroleum ether/ethyl acetate=1/1).

1. washwashed with brine (30 mL×3)
2. dry with materialdried over Na2SO4
3. filtrationfiltered
4. concentrationconcentrated
5. custompurified by flash chromotography (silica gel, petroleum ether/ethyl acetate=1/1)