Guanidine Hydrochloride → HCID 19955507, compound

HRID 1779386Notes

Reaction equation

HRID 1779386 reaction equation
C(O[CH:4]=[C:5]([C:17]#[N:18])[CH2:6][CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=1)C.Cl.[NH2:20][C:21]([NH2:23])=[NH:22].C(=O)([O-])[O-].[K+].[K+].NN1C=C(CCCC2C=CC(OC)=CC=2)C(N)=NC1>CN(C)C=O>[NH2:22][C:21]1[N:23]=[C:17]([NH2:18])[C:5]([CH2:6][CH2:7][CH2:8][C:9]2[CH:10]=[CH:11][C:12]([O:15][CH3:16])=[CH:13][CH:14]=2)=[CH:4][N:20]=1

Participants

6

Reactant 4

HCID 5742Guanidine HydrochlorideHCID 11430Potassium CarbonateHCID 19955455HCID 19955455, compoundHCID 53642355HCID 53642355, compound

Product 1

HCID 19955507HCID 19955507, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

This compound was prepared in a manner analogous to that of Example 2, Step E, using 0.8 gram (0.003 mole) of 1-ethoxy-2-cyano-5-(4-methoxyphenyl)-1-pentene, 1.3 grams (0.012 mole) of guanidine hydrochloride, and 2.7 grams (0.018 mole) of potassium carbonate in 15 mL of N,N-dimethylformamide. The yield of 1,4-diamino-5-[3-(4-methoxyphenyl)propyl]pyrimidine was 0.5 gram, mp 151°-154° C. The NMR spectrum was consistent with the proposed structure.

Workup

  1. customThis compound was prepared in a manner analogous to that of Example 2, Step E

Sources & evidence

ORD record
ord-f54f587d4add4d62903a3d0e9e25a40c
Source dataset
uspto-grants-1997_05
Patent number
US05627189

Reaction notes

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