Benzoyl chloride → Benzamide, N-propyl-

HRID 1781146Notes

Reaction equation

HRID 1781146 reaction equation
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:10]([NH2:13])[CH2:11][CH3:12]>C(OCC)(=O)C>[CH2:10]([NH:13][C:1](=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[CH2:11][CH3:12]

Participants

4

Reactant 2

HCID 7412Benzoyl chlorideHCID 7852Propylamine

Product 1

HCID 25354Benzamide, N-propyl-Yield 96%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Benzoyl chloride (10 mL, 86.2 mmol) in ethyl acetate (200 mL) was treated with propylamine. The precipitate was removed by filtration, and the solution was washed with 1M HCl, 5% NaHCO3, and brine, dried over MgSO4 and concentrated in vacuo to give the title compound in 96% yield.

Workup

  1. customThe precipitate was removed by filtration
  2. washthe solution was washed with 1M HCl, 5% NaHCO3, and brine
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-39484ed599c04b63b91693a7e1f09678
Source dataset
uspto-grants-1997_05
Patent number
US05631401

Reaction notes

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