Acetate → (E)-Ethyl 3-(6-chloropyridin-3-YL)acrylate

HRID 178236Notes

Reaction equation

HRID 178236 reaction equation
[C:22]([CH:23]=[CH2:24])(=[O:25])[O:26][CH2:27][CH3:28].[CH2:9]([N:10]([CH2:11][CH2:12][CH2:13][CH3:14])[CH2:15][CH2:16][CH2:17][CH3:18])[CH2:19][CH2:20][CH3:21].[Cl:1][c:2]1[n:3][cH:4][c:5]([Br:8])[cH:6][cH:7]1.[O-:35][C:36]([CH3:37])=[O:38].[O-:39][C:40]([CH3:41])=[O:42].[O:29]=[CH:30][N:31]([CH3:32])[CH3:33].[Pd+2:34]>>[Cl:1][c:2]1[n:3][cH:4][c:5]([CH:24]=[CH:23][C:22](=[O:25])[O:26][CH2:27][CH3:28])[cH:6][cH:7]1

Participants

7

Reactant 6

HCID 175Acetate2×HCID 6228DimethylformamideHCID 7622TributylamineHCID 8821Ethyl AcrylateHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 27344145-Bromo-2-chloropyridine

Product 1

HCID 53406713(E)-Ethyl 3-(6-chloropyridin-3-YL)acrylate

Sources & evidence

ORD record
ord-58ba629c8b824869b1fc16a2cecc1176
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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