反应详情

2-Cyanomethyl-5-methylbenzoic acid (16.3 g) and dimethylformamide (0.1 mL) were suspended in tetrahydrofuran (160 mL), and oxalyl dichloride (12.2 mL) was added dropwise under ice-cooling. After cease of foaming, the solvent was evaporated. The obtained residue was dissolved in tetrahydrofuran, and the solution was added dropwise to 28% aqueous ammonia solution under ice-cooling. After the completion of the reaction, the solvent was evaporated, and the precipitated crystals were collected by filtration to give 2-cyanomethyl-5-methylbenzamide (10.9 g).

1. temperaturecooling
2. customthe solvent was evaporated
3. dissolutionThe obtained residue was dissolved in tetrahydrofuran
4. additionthe solution was added dropwise to 28% aqueous ammonia solution under ice-
5. temperaturecooling
6. customAfter the completion of the reaction
7. customthe solvent was evaporated
8. filtrationthe precipitated crystals were collected by filtration