Hydrochloric Acid → HCID 57463076, compound

HRID 1783834Notes

Reaction equation

HRID 1783834 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([C:9]2[N:10]=[C:11]3[N:15]([C:16]=2[C:17]2[CH:22]=[CH:21][N:20]=[C:19]([NH:23][C@@H:24]4[CH2:29][CH2:28][CH2:27][N:26](C(OC(C)(C)C)=O)[CH2:25]4)[N:18]=2)[CH:14]=[CH:13][S:12]3)[CH:6]=[CH:7][CH:8]=1)#[N:2].[ClH:37]>C(OCC)(=O)C>[ClH:37].[C:1]([C:3]1[CH:4]=[C:5]([C:9]2[N:10]=[C:11]3[N:15]([C:16]=2[C:17]2[CH:22]=[CH:21][N:20]=[C:19]([NH:23][C@@H:24]4[CH2:29][CH2:28][CH2:27][NH:26][CH2:25]4)[N:18]=2)[CH:14]=[CH:13][S:12]3)[CH:6]=[CH:7][CH:8]=1)#[N:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57463075HCID 57463075, compound

Product 1

HCID 57463076HCID 57463076, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

The tert-butyl (3R)-3-({4-[6-(3-cyanophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrimidin-2-yl}amino)piperidine-1-carboxylate (2.90 g, 5.79 mmol) was dissolved in 20 mL of ethyl acetate and treated with 30 mL of 3.0 M HCl in ethyl acetate at room temperature (RT) overnight. Solid product was filtered, washed with ethyl acetate and dried under vacuum overnight to provide the title compound as a yellow solid. It was used without further purification. LCMS: 402 [M+H].

Workup

  1. filtrationSolid product was filtered
  2. washwashed with ethyl acetate
  3. customdried under vacuum overnight

Sources & evidence

ORD record
ord-1ccb2bec977b4fe6830c810c9bb88847
Source dataset
uspto-grants-2009_03
Patent number
US07501430B2

Reaction notes

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