Hydrochloric Acid → HCID 53628935, compound

HRID 1784660Notes

Reaction equation

HRID 1784660 reaction equation
Cl.C(OC([N:9]1[CH2:14][CH2:13][N:12]([C:15]2[N:20]([CH3:21])[C:19](=[O:22])[CH:18]=[C:17]([C:23]3[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=3)[N:16]=2)[CH2:11][CH:10]1[C:29]1[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][CH:30]=1)=O)(C)(C)C>C(OCC)(=O)C>[ClH:35].[Cl:35][C:32]1[CH:31]=[CH:30][C:29]([CH:10]2[CH2:11][N:12]([C:15]3[N:20]([CH3:21])[C:19](=[O:22])[CH:18]=[C:17]([C:23]4[CH:24]=[CH:25][N:26]=[CH:27][CH:28]=4)[N:16]=3)[CH2:13][CH2:14][NH:9]2)=[CH:34][CH:33]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 53628936HCID 53628936, compound

Product 1

HCID 53628935HCID 53628935, compoundYield 178.3%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

4N Hydrogen chloride in ethyl acetate was added to the solution of 2-(1-(tert-butoxycarbonyl)-2-(4-chlorophenyl)-piperazine-4-yl)-3-methyl-6-(4-pyridyl)pyrimidin-4-one (500 mg, 1.0 mmol) in ethyl acetate and stirred. Filtration and successive dryness gave the title compound (373 mg, 79%).

Workup

  1. filtrationFiltration and successive dryness

Sources & evidence

ORD record
ord-1c696d5240cc431587d259cc68331a13
Source dataset
uspto-grants-2009_03
Patent number
US07504411B2

Reaction notes

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